7th Training Course on

High-Throughput (HT)
Drug Metabolism/Disposition(DM/D)

Canal at dusk - © Holländska turistbyrån, Stockholm

May 26 - 30 • 2008 • Amsterdam • The Netherlands

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This is a Monday to Friday course comprising theoretical and practice-
oriented training in drug metabolism, disposition and safety, with special
emphasis on modern high-throughput aspects. The programme will start in the morning of Monday May 26, at 09.00 (Sunday, May 25 registration), and it will end on Friday, May 30, at 15.30.

Background
The EUFEPS Committee on Industrial Relations (CIR) initiated this
Course. Six successful Courses were previously given in 2002 - 2007. It is
concentrated to five full teaching days, including lectures, demonstrations and case discussions and organised in collaboration with the LACDR-Section of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit (VU-University), Amsterdam NL.

Goals and participants
Specific goals of the Course include:

• To learn to critically evaluate the basic concepts of HT technologies in drug metabolism/disposition
• To learn the possibilities but also the limitations of HT-drug metabolism/ disposition technologies in daily practices
• To stimulate interdisciplinary learning of HT drug metabolism/disposition
• To stimulate research in and applications of HT drug metabolism/disposition
• To prepare new industrial and academic recruits better to meet the challenges of HT technologies in drug metabolism/disposition

• To increase the general standard of the use of HT technologies in drug metabolism/disposition
• To attract long term funding for a permanent training centre in HT drug
  metabolism/ disposition
• To attract investments in HT drug metabolism/disposition technologies in academia, thereby improving the facilities for (undergraduate/graduate/PhD) training of future employees in industry and academia

• Post-doctoral/advanced PhD (or equal) level attendees from industry, CROs and innovative equipment and instrument manufacturers, as well as from academia
• Those working in pharmaceutical, bio-technological, bio-analytical, agro/fine chemical fields and in (bio)informatics
• Maximum 25 participants

International Scientific & Planning Committee
Chair:
Bernd Clement, Kiel DE

Additional Members:
Leo de Leede, Leiden NL
Rodolfo Gasser, Basel CH,
Barry Jones, Sandwich UK
Hans H. Lindén, Stockholm SE
Han van de Waterbeemd, Macclesfield, UK

Course Leaders:
Nico P.E. Vermeulen
Jan N.M. Commandeur, Amsterdam NL

Aim and Programme
The specific aim of the Course is:

• To update the participants (with different backgrounds) on basic theory and concepts of drug metabolism/disposition and its role in drug discovery, drug development and safety assessment
• To provide the participants with a balanced theoretical background on the latest developments of HT approaches and technologies in the field

MThe general format of the Course includes 2 –3 speakers (theory) per day and invited HT-equipment / technology providers presenting, during 2 hrs sessions, interactively, their own equipment / technology and demonstration material. There will be ample time for interaction, practical case studies and discussions led by the Course Leaders. A comprehensive Course Manual containing copies and relevant background material will be provided as well as a CD-rom containing lectures, cases and other relevant data.

Preliminary Programme

Sunday, May 25, 2008

Welcome and Registration at the Novotel Amsterdam

Monday, May 26, 2008

• Phase I-and II-enzymes: Enzymology and role in drug discovery/
  development
  Nico P.E. Vermeulen, Molecular Toxicology, LACDR, Amsterdam NL
• Pharmacogenetics of drug metabolising enzymes: methods and
  consequences
  Magnus Ingelmann-Sundberg, Molecular Toxicology, Karolinska Institute, Stockholm SE
• High-throughput pharmacokinetics: concepts and applications
  Tony J. Pateman, DMPK Consultant, Welwyn, Hertfordshire UK
• Introduction to ADME-Tox cases (incl. HT-aspects and idiosyncratic drug toxicities)
  Jan N.M. Commandeur, Molecular Toxicology, LACDR, Amsterdam NL

Tuesday, May 27, 2008

• Integration of HP-chemical analysis and biomolecular screening: HT aspects
  Hubertus Irth, Bioanalytical Chemistry, Vrije Universiteit, Amsterdam NL
• LC-MS/MS in HT drug metabolism and PK studies
  Richard Thompson, DMPK & Bioanalytical Chemistry, AstraZeneca R&D, Mölndal, SE
• Solubility and drug absorption - measurement and prediction
  John Comer, Sirius Analytical Instruments Ltd., Forest Row UK
• ADME-Tox cases (incl. HT-aspects and drug toxicities)
  Jan N.M. Commandeur, Molecular Toxicology, LACDR, Amsterdam NL

Wednesday, May 28, 2008

• In vitro testing of drug absorption: HT aspects
  Anthony Harrison, Pharmacodynamics, Dynamics and Metabolism, Pfizer Global Research & Development, Sandwich UK
• In vitro testing of drug metabolism: HT aspects
  Barry Jones, Pharmacodynamics, Dynamics and Metabolism, Pfizer Global Research & Development, Sandwich UK
• HT-screening technologies for Cytochrome P450 turnover/interaction assays
  David Stresser, Gentest/BD-Biosciences Discovery Labware, San Jose USA
• ADME-Tox cases (incl. HT-aspects and drug toxicities)
  Jan N.M. Commandeur, Molecular Toxicology, LACDR, Amsterdam NL

Thursday, May 29, 2008

• In silico modelling and prediction of drug metabolism and safety
  Liz Covey-Crump, Lhasa Ltd., Woodhouselane, Leeds UK
• Virtual ADME screening and in silico modelling of drug metabolism
  Matt Segall, Inpharmatica Ltd./Admensa, Cambridge UK
• ADME-Tox cases (incl. HT-aspects and drug toxicities)
  Jan N.M. Commandeur, Molecular Toxicology, LACDR, Amsterdam NL

Friday, May 30, 2008

• High throughput toxicity screening
  Mario Monshouwer, PK and Drug Metabolism, Roche, California, USA
• Genomics, proteomics and metabonomics in drug discovery and
  development
  Laura Suter-Dick, Drug Metabolism, F. Hoffmann-La Roche AG, Basel CH
• ADME-Tox cases (incl. HT-aspects and drug toxicities)
  Jan N.M. Commandeur, Molecular Toxicology, LACDR, Amsterdam NL

General time schedule
Teaching at 09.00 – 12.30 and at 14.00 – 17.30 and lunch at 12.30 – 14.00.

Location
Novotel, Rembrandtzaal (www.hotels.nl/amsterdam/novotel/)
Europaboulevard 10, 1083 AD, Amsterdam, NL

Registration, fees and deadline
Please complete the Course Registration Form and return it to the Course Secretariat.
The registration fee for the Course includes:

• Admission to all sessions
• All course documentation incl. CD-ROM
• Coffee breaks, lunches and the evening outing and dinner

Click for Registration Form (PDF)

The registration deadline April 11, 2008. After this date, contact the Course Secretariat for possibly free places due to cancellations.

Accommodation
To encourage and stimulate a high number of delegates to attend this important Training Course, the registration fee will be waived for every third industry and academy delegate, when registering three delegates, at the same time.
You get three and pay for two.

• A reservation of rooms can be made at the Novotel Amsterdam,
  Europaboulevard 10, NL-1083 AD Amsterdam, The Netherlands.
  Email: h0515@accor-hotels.com. Website: www.hotels.nl/amsterdam. novotel/ Phone +31 20 5411123, Fax +31 20 6462823, to utilise this option (rate ~EUR 138,-), contact the Novotel Amsterdam and refer to the HT-DMD Course.
• For other hotels, contact for example the Amsterdam Hotel Service,
  Damrak 7 (near Central Railway Station), NL-1012 LG Amsterdam,
  The Netherlands. Phone +31 20 5207000, Fax +31 20 6245999.
  Email sales@amsterdam-ts.nl Website: www.amsterdam-ts.nl.
• For low rate accommodation, contact the Amsterdam Hostels at:
  www.hotels.nl/amsterdam/novotel

Registration and Accommodation Cancellations
Pre-registered delegates who are unable to attend the Course will be refunded, except for an administrative fee of EUR 50,- provided the Course Secretariat receives a written notice of non-attendance, before April 7, 2008. No refunds can be made for cancellations received after this date. Substitutions may, however, be made at any time, provided the post-doctoral level (equivalent) requirements are fulfilling also for the replacement.

The European Federation for Pharmaceutical Sciences (EUFEPS)
EUFEPS was founded in 1991. Its mission is to advance excellence in the pharmaceutical sciences and innovative drug research and to represent the interests of scientists engaged in drug research and development, drug regulation and drug policymaking. Currently, it links 24 Member Societies in 23 countries. In addition, there are individual members and other supporting organisations.

Useful addresses

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