6th Training Course on

High-Throughput (HT)
Drug Metabolism/Disposition(DM/D)

May 21 - 25 • 2007 • Amsterdam • The Netherlands

Index » Prelimiary Programme » Click for Registration Form (PDF) » Useful Addresses Download a Flyer Download a Postcard Download the 2nd Announcement

This is a Monday to Friday course, comprising theoretical and practical training. Registration is Sunday afternoon, May 20. The programme will start in the morning of Monday, May 21, at 09.00, and it will end on Friday, May 25, at 15.30.

Background
EUFEPS Committee on Industrial Relations (CIR) initiated this Course. A successful Course was held in July 2002, June 2003, April 2004, April 2005 and May 2006. This is the second announcement of the next Course, which is slightly modified due to feedback from previous Courses. It is concentrated to five full teaching days, including lecturing and demonstrations, on Monday-Friday. It will be organised in collaboration with the LACDR-Section of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit (Free University), Amsterdam NL.

Goals and participants
Specific goals of the Course include:

• To stimulate interdisciplinary learning of HT drug metabolism/disposition.
• To learn to critically evaluate the basic concepts of HT technologies in drug metabolism/disposition.
• To learn the possibilities but also the limitations of HT-drug metabolism/ disposition technologies.
• To train attendees in the most relevant HT drug metabolism/disposition technologies.
• To stimulate research in and applications of HT drug metabolism/
  disposition.
• To prepare new industrial and academic recruits better to meet the
  challenges of HT technologies in drug metabolism/disposition.

• To increase the general standard of the use of HT technologies in drug metabolism/disposition.
• To attract long term funding (e.g. from the EC) for a permanent training centre in HT drug metabolism/disposition.
• To attract investments in HT drug metabolism/disposition technologies in academia, thereby improving the facilities for (undergraduate/graduate/PhD) training of future employees in industry and academia.

• Post-doctoral/advanced PhD (or equal) level attendees from industry, CROs and innovative equipment and instrument manufacturers, as well as from academia.
• Those working in pharmaceutical, bio-technological, bio-analytical, agro/fine chemical and (bio)informatics.
• Maximum 25 participants.

International Scientific & Planning Committee
Chair: Bernd Clement, Kiel DE
Course Leaders: Nico P.E. Vermeulen and Jan N.M. Commandeur, Amsterdam NL
Additional Members: Leo de Leede, Leiden NL, Rodolfo Gasser, Basel CH, Barry Jones, Sandwich UK, Hans H. Lindén, Stockholm SE and
Han van de Waterbeemd, Macclesfield, UK.

Aim and Programme
The specific aim of the Course is:

- to update the participants (with different backgrounds) on basic theory and concepts of drug metabolism/disposition and its role in drug discovery, drug development and safety assessment.

- to provide the participants with a balanced theoretical background on the latest developments of HT approaches and technologies in the field.

The general format of the Course includes several speakers (theory) per day, and invited equipment/ technology providers presenting, during interactive sessions, their own equipment/technology and demonstration material. There will be ample time for interaction, case studies, and discussions led by one of the Course leaders. A comprehensive Course Manual, containing copies and relevant background material will be provided. The intention is that real ADME-Tox cases should be dealt with, e.g. consisting of data/dossiers from industry and literature.

Preliminary Programme

Sunday, May 20, 2007

Registration at Novotel Amsterdam, and welcome

Monday, May 21, 2007

• Phase I-and II-enzymes: Enzymology and role in drug discovery/
  development
  Nico P.E. Vermeulen, Molecular Toxicology, LACDR, Amsterdam NL
• Pharmacogenetics of drug metabolising enzymes: methods and
  consequences
  Magnus Ingelmann-Sundberg, Molecular Toxicology, Karolinska Institute, Stockholm SE
• High-throughput pharmacokinetics: concepts and applications
  Tony J. Pateman, DMPK Consultant, Welwyn, Hertfordshire UK
• Introduction to ADME-Tox cases (incl. HT-aspects and idiosyncratic drug toxicities)
  Jan N.M. Commandeur, Molecular Toxicology, LACDR, Amsterdam NL

Tuesday, May 22, 2007

• Integration of HP-chemical analysis and biomolecular screening: HT aspects
  Hubertus Irth, Bioanalytical Chemistry, Vrije Universiteit, Amsterdam NL
• LC-MS/MS in HT drug metabolism studies
  Richard Thompson, DMPK & Bioanalytical Chemistry, AstraZeneca R&D, Mölndal, SE
• Solubility and drug absorption - measurement and prediction
  John Comer, Sirius Analytical Instruments Ltd., Forest Row UK
• ADME-Tox cases (incl. HT-aspects and drug toxicities)
  Jan N.M. Commandeur, Molecular Toxicology, LACDR, Amsterdam NL

Wednesday, May 23, 2007

• In vitro testing of drug absorption: HT aspects
  Anthony Harrison, Pharmacodynamics, Dynamics and Metabolism, Pfizer Global Research & Development, Sandwich UK
• In vitro testing of drug metabolism: HT aspects
  Barry Jones, Pharmacodynamics, Dynamics and Metabolism, Pfizer Global Research & Development, Sandwich UK
• HT-screening technologies for Cytochrome P450 turnover/interaction assays
  David Stresser, Gentest/BD-Biosciences Europe, Heidelberg DE
• ADME-Tox cases (incl. HT-aspects and drug toxicities)
  Jan N.M. Commandeur, Molecular Toxicology, LACDR, Amsterdam NL

Thursday, May 24, 2007

• In silico modelling and prediction of drug metabolism and safety Liz Covey-Crump, Lhasa Ltd., University of Leeds, Leeds UK
• Make the most of your ADME data: Combining in silico and HT DM/D data for effective decision-making
  Matt Segall, Inpharmatica Ltd, Cambridge Science Park, Cambridge UK
• ADME-Tox cases (incl. HT-aspects and drug toxicities)
  Jan N.M. Commandeur, Molecular Toxicology, LACDR, Amsterdam NL

Friday, May 25, 2007

• High throughput toxicity screening
  Mario Monshouwer, PK and Drug Metabolism, Roche, California, USA
• Genomics, proteomics and metabonomics in drug discovery and
  development
  Laura Suter-Dick, Drug Metabolism, F. Hoffmann-La Roche AG, Basel CH
• ADME-Tox cases (incl. HT-aspects and drug toxicities)
  Jan N.M. Commandeur, Molecular Toxicology, LACDR, Amsterdam NL

• Admission to all sessions
• All training course documentation
• Coffee breaks, lunches and the evening outing and dinner

The registration deadline April 7, 2007. After this date, contact the Course Secretariat for possibly free places due to cancellations.

• A reservation of rooms can be made at the Novotel Amsterdam,
  Europa-boulevard 10, NL-1083 AD Amsterdam, The Netherlands.
  Email: h0515@accor-hotels.com.
  Website: www.hotels.nl/amsterdam.
  novotel/ Phone +31 20 5411123, Fax +31 20 6462823, to utilise this option (rate ~EUR 138,-), contact the Novotel Amsterdam and refer to the HT-DMD Course.
• For other hotels, contact for example the Amsterdam Hotel Service, Damrak 7 (near Central Railway Station), NL-1012 LG Amsterdam, The Netherlands. Phone +31 20 5207000, Fax +31 20 6245999.
  Email sales@amsterdam-ts.nl Website: www.amsterdam-ts.nl.
• For low rate accommodation, contact the Amsterdam Hostels at:
  www.hostelamsterdam.com.

Registration and Accommodation Cancellations
Pre-registered delegates who are unable to attend the Course will be refunded, except for an administrative fee of EUR 50,- provided the Course Secretariat receives a written notice of non-attendance, before March 25, 2007. No refunds can be made for cancellations received after this date. Substitutions may, however, be made at any time, provided the post-doctoral level (equivalent) requirements are fulfilling also for the replacement.

The European Federation for Pharmaceutical Sciences (EUFEPS)
EUFEPS was founded in 1991. Its mission is to advance excellence in the pharmaceutical sciences and innovative drug research and to represent the interests of scientists engaged in drug research and development, drug regulation and drug policymaking. Currently, it links 24 Member Societies in 23 countries. In addition, there are individual members and other supporting organisations.

Useful Addresses

Course leadership N.P.E. Vermeulen and J.N.M. Commandeur LACDR Section of Molecular Toxicology Department of Pharmacochemistry Vrije Universiteit (Free University) De Boelelaan 1083, NL-1081 HV Amsterdam, The Netherlands Phone +31 20 5987590 Fax +31 20 5987610 Email npe.vermeulen@few.vu.nl Email jnm.commandeur@few.vu.nl Website www.chem.vu.nl/far/	Hotel reservation in Amsterdam Novotel Amsterdam Europaboulevard 10 NL-1083 AD Amsterdam, The Netherlands Phone +31 20 5411123 Fax +31 20 6462823 Email ho515@accor-hotels Website www.hotels.nl/amsterdam/novotel/
Co-ordination, registration and secretariat Hans H. Lindén and Annika Nyman EUFEPS Secretariat PO Box 1136 SE-111 81 Stockholm Sweden Phone +46 8 723 50 00 Fax +46 8 4113217 Email secretariat@eufeps.org	Amsterdam Hotel Service Damrak 7 (near Central Railway Station) NL-1012 LG Amsterdam, The Netherlands. Phone +31 20 5207000 Fax +31 20 6245999 Email sales@amsterdam-ts.nl Website www.amsterdam-ts.nl Amsterdam Hostels Website www.hostelamsterdam.com

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Sponsor of this Training Course
The European Federation for Pharmaceutical Sciences (EUFEPS) and the Leiden-Amsterdam Center for Drug Research (LACDR), Section of
Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit (Free University) are delighted to have the below organisation as sponsor of this important Training Course and wish to extend our grateful thanks

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