2nd Conference
on
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||
|
Scope
and aim
This conference is the second in the series on Optimising Drug
Delivery and Formulation initiated in 2003 in Versailles. Due
to the success of the EUFEPS/APGI cooperation in the organisation
of 2003 conference on New Challenges in Drug Delivery, it has
been decided to hold this scientific event regularly. The topic
of this year focuses on the tools which can be employed to better
characterise and evaluate the different drug delivery systems
at all stages of their creation, from the first concepts in
designing the delivery systems, to the assessment of the formulation
progress and the control of the final medicine.
The main objectives of this conference are not only to give
tools for a safer and more efficient formulation, but also to
present new physico-chemical techniques, which can be used in
this perspective.
The evaluation can deal with:
-
The progress of formulation at its different stages
-
The assessment of dermal, epithelial, tissular, cellular, nuclear permeation
-
The study of excipient, conjugate and drug delivery system characteristics, bioavailability, absorption, safety, stability, etc.
-
All the physico-chemical and biological techniques used for such assessments: microspcopic, thermal, spectral, rheological, and structural studies as well as cell cultures.
Key Topics and Issues
-
How can in silico methods drive valuable formulation?
-
To what extent can in vitro methods be accepted by health authorities?
-
What are the key points to control in drug delivery systems for the different routes?
-
Are there true new technologies or only up-dated methods?
-
Are the in vitro/in vivo correlations pure utopia?
-
What alternatives to in vivo studies?
-
New cell lines for specific assays.
Breakout
Sessions
There will be a number of breakout sessions. Examples
of topics are:
I Optimising predictive evaluation tests
II Cell models simulating biological tissues
Oral
and Poster contributions
Scientific contributions relating to the conference scope and
aim will be welcome and considered either for oral or poster
presentations.
Oral contributions will be selected among all the contribution
abstracts received. They will focus more specifically on the
evaluation (at any level of the formulation) of drug delivery
systems, including three administration routes, i.e. oral/gastro-intestinal,
dermal/transdermal and mucosal, as well as on carrier systems.
The registration fee will be waived for the main author
(speaker) of the selected oral contributions.
Abstracts should be submitted to the EUFEPS Secretariat, both
as an e-mail attachment and as a hard copy with indication of
a wish for oral presentation. Submission deadline is October
1, 2005.
Click for Editorial Instructions.
Exhibition
Companies are invited to exhibit at the Conference. For information
on layout, costs, etc., as well as an exhibition registration
form, please contact the EUFEPS Secretariat or the APGI Secretariat.
Special discount will be allowed to companies having already
exhibited at PharmSciFair. (www.pharmscifair.org).
Language
English will be the language of the Conference. No simultaneous translation will be provided.
Organiser
EUFEPS was founded in 1991. Its mission is to advance excellence in the pharmaceutical sciences and innovative drug research
and to represent the interests of scientists engaged in drug research
and development, drug regulation and drug policymaking. Currently,
it links 24 Member Societies in 24 countries. In addition, there
are Individual Members of EUFEPS.
Final Programme
Sunday,
November 20, 2005
Welcome Reception
Monday,
November 21, 2005
| 09:15 | Welcome Elias Fattal, APGI President, Châtenay Malabry FR |
| 09:20 | APGI
and EUFEPS Awards Dominique Duchêne, EUFEPS, Châtenay Malabry FR |
| Session
I: 09:30-10:05 |
In silico evaluation |
| Chair:
Dominique Duchêne, Paris-Sud University,
Châtenay Malabry FR Invited lecture |
|
| 09:30 | In
silico approaches: Toys or tools for drug delivery
system developer? Olavi Pelkonen, University of Oulu, Oulu FI |
| 10:05-10:35 | Coffee/Tea/Posters/Exhibition |
| Session
2: 10:35-12:20 |
Regulatory aspects of evaluation |
| Chair:
Christos Reppas, Athens University, Athens GR Invited lecture |
|
| 10:35 | Monographs
on dosage forms and pharmaceutical technical procedures
- Tools of European Pharmacopoeia in the drug delivery evaluation Christina Graffner, Medical Product Agency, Uppsala SE |
| 11:10 | Regulatory aspects
of delivery systems Georg Wade, EMEA, London UK |
| 11:45 | Pharmaceutical
development and regulatory expectations in Europe Philippe Maincent, AFSSAPS, Saint Denis FR |
| 12:20-14:00 | Lunch/Poster Session |
| Session
3: 14:00-15:45 |
Evaluation of oral/gastro-intestinal drug delivery systems I |
| Chair:
Claus Michael Lehr, University of Saarlandes, Saarbrücken
DE Invited lecture |
|
| 14:00 | In
vitro vs. canine data for assessing oral drug absorption Christos Reppas, Athens University, Athens GR |
| 14:35 | What happens
to particulate systems in the gastro-intestinal tract? Gilles Ponchel, Paris-Sud University, Châtenay Malabry FR |
| 15:10 | Challenges and
strategies for the intestinal delivery of proteins and peptides Randall J Mrsny, Cardiff University, Cardiff UK |
| 15:45-16:15 | Coffee/Tea/Posters/Exhibition |
| Session
4: 16:15-17:30 |
Evaluation of oral/gastro-intestinal drug delivery systems II |
| Chair:
Olavi Pelkonen, University of Oulu, Oulu FI Technology lecture |
|
| 16:15 | Simulation
of non-linear absorption for metabolised and transported
drugs: Implications for site selective drug delivery Michael B Bolger, Simulations Plus, Lancaster CA USA |
| Oral contributions | |
| 16:50 | Influence of
gastric residence time on drug dissolution from pellets:
Prediction of in vivo dissolution profile by a
mathematical model Marija Bogataj, University of Ljubljana, Ljubljana SI |
| 17:10 | Delineation
of passive and carrier mediated transport parameters of
poorly water soluble drugs subject to apical efflux with
phospholipids as solubilizers in Caco-2 cells using mathematical
modelling Georgios Imanidis, University of Basel, Basel CH |
| 17:30-19:00 | Breakout Sessions I and II |
| Breakout
Session I: Optimising predictive evaluation tests Chairman: Peter York, Bradford University, Bradford UK Breakout Session II: Cell models simulating biological tissues Chairman: Paul Gellert, AstraZeneca, Alderley Park UK |
|
Tuesday,
November 22, 2005
| Session
5: 09:00-10:10 |
Evaluation of mucosal drug delivery systems (ocular/nasal/pulmonary) I |
| Chair:
Jean-Christophe Leroux, University of Montreal,
Montreal CA Invited lectures |
|
| 09:00 | Ocular
drug delivery: Computational and cell culture study methods Arto Urtti, University of Kuopio, Kuopio FI |
| 09:35 | Pulmonary drug
delivery: Design and evaluation of formulation and device Paolo Colombo, University of Parma, Parma IT |
| 10:10-10:40 | Coffee/Tea/Posters/Exhibition |
| Session
6: 10:40-12:40 |
Evaluation of mucosal drug delivery systems (ocular/nasal/pulmonary) II |
| Chair:
Paolo Colombo, University of Parma, Parma IT Invited lectures |
|
| 10:40 | Tissue
based system to mimic pulmonary mucosa, nature, value and
limitations in evaluation process Claus Michael Lehr, University of Saarlandes, Saarbrücken DE |
| Oral contributions | |
| 11:25 | Investigation
into the cellular uptake mechanism of the PEGylated polycyanoacrylate
nanoparticles in the rat brain endothelial cells Hyun Ryoung Kim, University of Paris-XI, Paris FR |
| 11:45 | Salmonella-like
nanoparticles for oral targeting Hesham H Salman, University of Navarra, Navarra, SP |
| Technology lecture | |
| 12:05 | In vitro
models to study the transport of carrier systems across
biological membranes Udo Bock, Across Barriers, Saarbrücken DE |
| 12:40-15:10 | Lunch/Poster Session |
| Session
7: 14:00-15:10 |
Evaluation of drug carriers I |
| Chair:
Elias Fattal, Paris-Sud University, Châtenay
Malabry FR Invited lectures |
|
| 14:00 | pH
determination at the surface of dispersed systems Catherine Dubernet, Paris-Sud University, Châtenay Malabry FR |
| 14:35 | In vivo
assessment of the targeting efficiency of taxane core-shell
nanocarriers to solid tumours Jean-Christophe Leroux, University of Montreal, Montreal CA |
| 15:10-15:40 | Coffee/Tea/Posters/Exhibition |
| Session
8: 15:40-17:15 |
Evaluation of drug carriers II |
| Chair:
Randall J Mrsny, Cardiff University, Cardiff UK Technology lecture |
|
| 15:40 | Specific
evaluation of drug carrier systems Emilienne Soma, BioAlliance, Paris FR |
| Oral contributions | |
| 16:15 | Liposomal formulations
of merphalan lipophilic prodrug equipped with SiaLex –determinant
cause prolong therapeutic effect on spontaneous mammary
cancer Ekaterina Moiseeva, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow RU |
| 16:35 | Physico-chemical
characterization of nanocapsules polymeric wall using a
fluorescent benzimidazole probe Adriana R Pohlmann, Universidade Federal do Rio Grande do Sul, Porto Alegre BR |
| 16:55 | A new approach
for in vitro testing bioequivalence of dermal products Elka Touitou, The Hebrew University of Jerusalem, Jerusalem IL |
Wednesday,
November 23, 2005
| Session
9: 09:00-10:45 |
Evaluation of dermal and transdermal delivery systems I |
| Chair:
Arto Urtti, University of Kuopio, Kuopio FI Invited lectures |
|
| 09:00 | Diffusion
model-based optimisation of skin permeation and its enhancement Fumiyoshi Yamashita, University of Kyoto, Kyoto JP |
| 09:35 | Measurement
and prediction of the rate and extent of drug delivery into
and through the skin Richard Guy, University of Bath, Bath UK |
| Technology lecture | |
| 10:10 | Evaluation
models for dermal and ungual drug delivery Marc Brown, MedPharm, Charlbury UK |
| 10:45-11:15 | Coffee/Tea/Posters/Exhibition |
| Session
10: 11:15-12:45 |
Evaluation
of dermal and transdermal delivery systems II Evaluation of mucosal drug delivery systems (ocular/nasal/pulmonary) III |
| Chair:
Richard Guy, University of Bath, Bath UK Invited lectures |
|
| 11:15 | Intradermal
delivery of vaccine antigens: Review of state of art Philippe E Laurent, Beckton Dickinson, Le Pont de Clay FR |
| 11:50 | The
performance of nanocarriers for transmucosal drug delivery:
Is it possible to predict efficacy? Maria Blanco Prieto, University of Navarra, Pamplona ES |
| Oral contribution | |
| 12:25 | Terbafine-based
nail lacquers: Ex vivo study on permeation through bovine
hoof membranes Daniela Monti, University of Pisa, Pisa IT |
| Session
11: 12:45-13:05 |
Breakout session reports |
| Chair: Elias Fattal, Paris-Sud University, Châtenay Malabry FR | |
| 12:45 | Optimising
predictive evaluation tests Peter York, Bradford University, Bradford UK |
| 12:55 | Cell
models simulating biological tissues Paul Gellert, AstraZeneca, Alderly Park UK |
| Conclusions | |
| 13:05-13:15 | Elias Fattal, APGI President, Paris-Sud University, Châtenay Malabry FR |
| “SPECIAL EVENT” | |
| 14:00-17:00 | Ceremony making the retirement of Professor Dominique Duchêne |
| 17:00-19:00 | Reception in Honour of Professor Dominique Duchêne |
| All conference delegates are warmly invited to this ceremony. Please confirm your participation by sending an e-mail to APGI (apgi.apgi@cep.u-psud.fr). | |
Welcome
Reception
The Welcome Reception, on Sunday, November 20, at 19:30, will
take place in the beautiful settings of the Hôtel de France,
a historic site from the 18th century, located 5 rue Colbert,
Versailles ( 5
on map).
Location
The Conference will take place at the Palais des Congrès
de Versailles, 10 rue de la Chancellerie, 78000 Versailles (
1 on map), Tel
+33 1 30978900, Fax +33 1 30211582.
How
to get there
To reach Versailles from:
Orly airport, taxi, travelling time around 35 min at
an approximate cost of EUR 55
Roissy Charles de Gaulle airport, taxi, travelling
time around 50 min at an approximate cost of EUR 80. There is
also an Air France Bus Shuttle (N° 4) between the Charles
de Gaulle Airport and the Gare Montparnass (EUR 12) and from
Montparnasse station to Versailles, please see below
Paris Montparnasse station, by RER-train, travelling
time around 20 min at an approximate cost of EUR 2.60
Paris Saint-Lazare station, by RER-train, travelling
time around 30 min at an approximate cost of EUR 2.60
Paris by car, via motorways A13 and A12, travelling
time around 20 min
Registration Fees (EUR)
| (VAT 19,6 %) | Before September 15, 2005 |
After September 15, 2005 |
| Industrial delegate | 950
+ VAT |
1250
+ VAT |
| Academic/Government delegate | 450
+ VAT |
600
+ VAT |
| Student delegate | 225
+ VAT |
300
+ VAT |
The Registration Fee (EUFEPS or APGI Membership and PharmSciFair delegates 10 % reduction) includes all conference documentation, all coffee breaks, two lunches and the Welcome Reception. The cost for hotel accommodation and travel is not included in the registration fee.
Cancellations
Pre-registered delegates who are unable to attend the Conference
will be refunded, except for an Administrative Fee of EUR 40,
provided the Conference Secretariat receives a written notice
of non-attendance, before October 31, 2005. No refunds can be
made for cancellations received after this date. Substitutions
may, however, be made at any time. The name of the substitute/s
should be forwarded to the Conference Secretariat.
Accommodation
Delegates have to make their own reservation. Recommended hotels
are listed in the following page
Palais des Congrès and Accommodation in Versailles
 |
Palais
des Congrès de Versailles 10, rue de la Chancellerie Tel +33 1 30 97 89 00 Fax +33 1 30 32 15 82 |
 |
Hôtel
le Versailles *** EUR 94 – 131 7, rue Sainte Anne Tel +33 1 39 50 64 65 Fax +33 1 39 02 37 85 www.hotel-le-versailles.fr |
 |
Le
Paris Hôtel ** EUR 81 – 120 14, avenue de Paris Tel +33 1 39 50 56 00 Fax +33 1 39 50 21 83 www.paris-hotel.fr |
 |
Sofitel
de Versailles **** EUR 182 – 202 2 bis, avenue de Paris Tel +33 1 39 07 46 46 Fax +33 1 39 07 46 47 www.sofitel.com please, mention “EUFEPS/APGI Conference” |
 |
Hôtel
de France *** EUR 128, breakfast included 5, rue Colbert Tel +33 1 30 83 92 23 Fax +33 1 30 83 92 24 www.hotelfrance-versailles.com please, mention “EUFEPS/APGI Conference” |
||
 |
Hôtel
la Résidence du Berry *** EUR 115 – 140, breakfast included 14, rue d’Anjou Tel +33 1 39 49 07 07 Fax +33 1 39 50 59 40 www.hotel-berry.com please, mention “EUFEPS/APGI Conference” |
 |
Hôtel
du Cheval Rouge ** EUR 65 – 69 18, rue André Chénier Tel +33 1 39 59 03 03 Fax +33 1 39 50 61 27 www.chevalrouge.fr.st |
Click for Conference Registration Form
Additional
Information
Updated information on this conference will be posted here and
on the APGI Website (www.apgi.org).
Alternatively, contact the EUFEPS Secretariat or the APGI Secretariat
(addresses below) for copies of announcements, the preliminary
programme, registration form and hotel reservation form. Also
inform your colleagues about the Conference, telling them about
it and/or forwarding electronic or other material to them.
| Useful
addresses |
|
| EUFEPS
secretariat |
APGI
secretariat |
The European Federation for Pharmaceutical Sciences – EUFEPS
Box 1136 SE - 111 81 Stockholm, Sweden
Tel +46 8 7235000 Fax +46 8 4113217 Email secretariat@eufeps.org
