EUFEPS Conference
on
When Poor Solubility
Becomes an Issue:
From Early Stage to Proof of Principles

April 26-27 •
2006 • Centro Congressi GSK
• Verona •
Italy
A Unique Discussion
Forum for Scientists from the Pharmaceutical Industry, Regulatory
Agencies and Academic Institutions
The Conference opens
on Wednesday, April 26, 2006, at 09:00 (Pre-registration on
Tuesday, April 25) and it closes on Thursday, April 27, 2006,
at 17.30.
Invitation
This Conference is a new initiative by the EUFEPS Committee
on Industrial Relations (CIR). Obviously, it will address an
important issue in the development of new medicines. It is intended
for all those struggling with such problems, as well as for
students and young scientists entering the field.
Scope
and Aim
The pressing challenge pharmaceutical scientists (product-development
scientists) have to face is the poor solubility of drug candidates.
In a scenario where an increasing number of drug molecules are
generated (high-throughput discovery screening methods, combinatorial
synthesis, etc.), the impact of biopharmaceutical properties,
including solubility, on drug development tend to be underestimated.
Nonetheless, water insolubility can hamper or completely halt
new drug development.
This Conference will explore the physicochemical and biopharmaceutical
properties important in order to have a ”drugable”
candidate together with formulation strategies to overcome insolubility-related
hurdles during “hit-to-lead” research. In this EUFEPS
conference highly experienced leaders from industry and academia
in areas of preformulation, product development (pre-clinical
and clinical) and in silico modelling will walk participants
through the key tools available in order to recognise if a solubility
problem would be an issue in the developability of a drug substance.
Discussion sessions will facilitate open dialog among participants
from drug discovery and development.
Conference
Objectives and Attributes
-
Bring together scientists from industry and academia and PhD
students from diverse disciplines of pharmaceutical sciences,
physical pharmacy, biopharmaceutics, pharmacokinetics and
modelling and clinical pharmacology
-
Understand the relevance of preformulation in processes of
drug discovery and drug development
-
Review current techniques and strategies for drug candidate
selection and formulation
-
Explore the linkage of in vitro and preclinical in
vivo data to formulation performance in humans
-
Contribute to the development of tools for the prediction
and measurement of drug-like properties and application in
discovery
-
View Posters offering unique experience and insight
-
Meet in a learning environment conducive to thoughtful consideration
and interaction
Format
& Preliminary Programme
Using a similar format to previous EUFEPS conferences, key segments
of the process are broken down into a number of sessions, each
with lectures and discussions.
Scientific
& Planning Committee
Hendrik de Jong, I.R.I.S. Servier International Research
Institute, Courbevoie FR; Dionigio Franchi, GlaxoSmithKline,
Verona IT; Franck Leveiller, AstraZeneca R&D, Lund
SE; Hans H. Linden, EUFEPS, Stockholm SE; Sven
Stegemann, Capsugel, Bornem BE
Exhibition
Information
Companies are welcome to participate as an exhibitor at this
Conference. The Conference delegates are academics, industrialists,
regulators and students which will give you a unique opportunity
to meet experts in your field. The exhibition offers every opportunity
to promote and position your company, your products, your services,
your expertise and your specialists, facilitating your contact
with them, predicting their needs and shaping future collaboration.
Click for Application
and Contract form.
Sponsorship
Opportunities
To sponsor this Conference and by this enable quality meetings
on key topics, contact the Exhibition Organiser, Chris Hanney
at Health Links (chrishanney@btclick.com) or
the EUFEPS Executive Director, Hans H Lindén (hans.linden@eufeps.org).

To find out more about sponsorship and exhibition opportunites,
please visit our partner Health Links.
Oral
and poster contributions
Scientific contributions relating to the scope and aim of the
Conference will be welcome and considered for poster presentations.
Abstracts should be submitted to the EUFEPS Secretariat, both
as an email attachment and as a hard copy.
Submission deadline is February 20, 2006.
Click for Editorial
Instructions.
Student
Attendance Package
Funds are being raised for a Student Attendance Package. It
is a new EUFEPS initiative, which would provide a substantial
number of qualified students from all European countries to
attend this Conference. The package would include free registration
and free accommodation (3 nights). The minimum target number
of participating students would equal one student per European
country (42), but more would be welcome (up to 1/4 to 1/3 of
the total number of delegates at the conference). Also, should
EUFEPS Member Societies want to support some student(s), i.e.
pay for student registration and accommodation, this would entitle
the same society to an additional student for free. If more
money would be raised than actually needed, this money would
be saved for new initiatives, along the same lines, in a “EUFEPS
Fund for Research Training and Education”.
To qualify for this Conference, students should be PhD or Master
Degree Students, who submit a recommendation letter from supervisor
+ a short biography + an up to one page poster abstract or an
up to one page description of interest area and work performed
by the student as part of the PhD or Master Programme, by January
31, 2006, to the EUFEPS Secretariat, attention Annika Nyman
(for address, see ”Useful Addresses”).
Review of documents received and selection of students will
be done, by a special committee, during February 2006.
Language
English will be the language of the Conference. No simultaneous
translation will be provided.
Organiser
EUFEPS was founded in 1991. Its mission is to advance excellence
in the pharmaceutical sciences and innovative drug research,
and to represent the interests of scientists engaged in drug
research and development, drug regulation and drug policymaking.
Currently, it links scientific societies and associations in
24 European countries and there are around 600 individual members
of EUFEPS.
Verona
We would like to welcome you to Verona, which is the city of
the most famous lovers in history: Romeo and Juliet. Verona
has much more to offer and one of the most famous monuments
in town is the Roman Amphitheatre, commonly known as The Arena.
This Roman theatre is one of the biggest (and best preserved)
theatres from the Roman Empire times. There are place for more
than 22,000 spectators. Nowadays world famous operas are performed
in the Theatre every summer. Although the building is now used
for operas and other cultural shows, its original use was crueller:
the famous Gladiators fights. In front of the Arena you will
find the ’Piazza Bra’ and in front of this square
you have the ’Palazzo Barbieri’ which is the Town
Hall finished in 1883. Other interesting buildings are the ’Gran
Guardia’ Palace, a 1610 Sanmicheli inspired building,
and the ’Palazzo Guastaverza’, a Sanmicheli work.
Final
Programme
Wednesday,
April 26, 2006 
Welcome,
Introduction and Opening Remarks
Christian
R Noe, EUFEPS President, University of Vienna, Vienna AT;
Franck Leveiller, Conference Chairman, AstraZeneca
R&D, Lund SE
Keynote presentation:
Overview on solubility and bioavailability issues
Gordon L Amidon, University of Michigan, Ann Arbor
MI USA
Session
I: Physical/chemical properties of the drug substance
Chairman: Hendrik de Jong, Servier International
Research Institute, Courbevoie FR
-
Understanding solubility of the molecules
Andrea Casazza, GlaxoSmithKline, Verona IT
- Crystal structure,
polymorphism
Ingvar Ymen, AstraZeneca R&D, Södertälje
SE
- Structural aspects
of salt formation: Salt as supramolecular entities
Dimitris Papoutsakis, Novartis Institutes for BioMedical
Research, Cambridge MA USA
- Crystal engineering
and particle design
Peter York, University of Bradford, Bradford UK
Session
II: Biopharmaceutical evaluation focused on drug substance
selection
Chairman: Valentino J Stella, University of Kansas,
Lawrence KS USA
- In vitro
absorption models to assess drug absorption
Brian Henry, Pfizer Global R&D, Sandwich UK
- Prediction of human
oral absorption, in drug discovery, using in silico models
Ronnie Patersson, AstraZeneca R&D, Charnwood, Leicestershire
UK
- Simulation of
GI tract absorption
GlaxoSmithKline,
Hertfordshire UK
- Biopharmaceutical
tools to assess developability of poorly soluble drug substances
Jan Van Gelder, Lilly Development Centre, Mont-Saint-Guibert
BE
Session
III: Drug candidate selection
Chairman: Sven Stegemann, Capsugel, Bornem BE
- Influencing candidate
selection to minimise development impact
Christopher Spancake, GlaxoSmithKline, Research Triangle
Park NC USA
- Strategies for lead
drug substance optimisation: Drug delivery concepts
Ward Smith, Pfizer Global R&D, Groton CT USA
- Approaches for the
rapid transition of drug substances and formulations into human
studies
Ian Wilding, Pharmaceutical Profiles, Nottingham UK
Panel
Discussion
Chairmen: Hendrik de Jong, Servier International Research
Institute, Courbevoie FR, Sven Stegemann, Capsugel,
Bornem BE, Valentino J Stella, University of Kansas,
Lawrence KS USA
Bus shuttle from
Conference Center for a Welcome Dinner at the ’Restaurant
Teodorico’ – located on a hill in town with a striking
view of Verona.
Thursday,
April 27, 2006 
Welcome
and introduction of keynote presentation
Dionigio
Franchi, GlaxoSmithKline, Verona IT
Keynote presentation:
Strategies to overcome poor solubility
Valentino J Stella, University of Kansas, Lawrence
KS USA
Session
IV: Successful formulation strategies for bioenhancement
Chairman: William Charman, Monash University, Parkville
Victoria AU
-
Nano-particles formulation of poorly soluble drugs
Lennart Lindfors, AstraZeneca R&D, Mölndal
SE
-
Cyclodextrins to enhance solubility
Marcus Brewster, Janssen Pharmaceutica NV, Beerse
BE
-
Lipids and the absorption of lipophilic drugs
William Charman, Monash University, Parkville
Victoria AU
-
Micellisation and microemulsions
Jayne Lawrence, Kings College London, London
UK
-
Self emulsified systems as drug delivery
Hassan Benameur, Capsugel, Colmar FR
-
Sugar glass dispersions enhancing the dissolution rate
of lipophilic drugs
Erik HW Frijlink, Groningen University, Groningen
NL
-
Modulation of bioavailability of carotenoids in humans
Myriam Richelle, Nestle Research Center, Lausanne
CH
Session
V: Biopharmaceutical evaluation of drug delivery
systems
Chairman: Peter York, University of Bradford, Bradford
UK
-
In vitro dissolution systems: Bio relevant dissolution
tests and a priori prediction of plasma profiles
Jennifer B Dressman, Goethe University, Frankfurt
DE
-
Evaluation of the in vivo performance of formulation
principles:
What to learn from imaging studies?
Werner Weitschies, Ernest Moritz Arndt University,
Greifswald DE
-
In vitro/in vivo correlation:
Regulatory perspectives
Carla Caramella, University of Pavia, Pavia I
Panel
Discussion
Chairmen: William Charman, Monash University, Parkville
Victoria AU, Jennifer B Dressman, Goethe University,
Frankfurt DE, Dionigio Franchi, GlaxoSmithKline,
Verona IT
Location
The Conference will take place in the Centro Congressi GSK,
Centro Ricerche, Via A. Fleming 4, Verona IT.
Public
transport from Verona Airport
Verona airport is situated just 12 km from the centre of
town. It is accessible via car, bus, rail and taxi.
A shuttle-bus operates to and from Verona Railway Station
and the Airport every 20 minutes from 06:10-23:35.
Taxi, travelling time around 15 minutes at an approximate
cost of EUR 25.
During the Conference, a shuttle-bus service from the city
center to the Centro Congressi GSK will be available.
Registration
The registration fee (EUFEPS Membership 10% reduction) includes
all conference documentation, all coffee breaks, two lunches
and one conference dinner. The cost for hotel accommodation
and travel is not included in the registration fee.
Click for online
registration
Click for Registration
Form (PDF)
Conference Registration Fees (EUR)
(incl.VAT 20%)
|
EUFEPS |
EUFEPS
|
EUFEPS
|
EUFEPS |
Members
before
February 20, 2006
|
Standard
Fee
before
February 20, 2006
|
Members
after
February 20, 2006
|
Standard
Fee
before
February 20, 2006 |
Industrial
delegate
|
1080
|
1200
|
1400
|
1550 |
Academy
delegate
|
630
|
700
|
840
|
930 |
Government
delegate
|
630
|
700
|
840
|
930 |
Student
delegate
|
270
|
300
|
360
|
400 |
See also ’Student
Attendance Package’.
Students
Participants applying for student fees should include proof
of their student status (a photocopy of the university identity
card).
Confirmation
In order to receive confirmation of registration by email,
please make sure to indicate the email address on the registration
form! Confirmation will be sent upon receipt of payment.
Alterations
Alterations to your registration must be made in writing
and sent to Congrex by email or fax.
Inquiries
Please direct all inquiries regarding registration or payment
to Congrex at: E-mail wpsbi.registration@congrex.se
Phone +46 8 4596600. Fax +46 8 6619125
Hotel
Reservation
Hotel reservations can be made on the attached hotel reservation
form. The hotels are all situated in the city centre of
Verona and the Conference venue is accessible with shuttle
bus transportation.
| Hotel
Rates
|
| |
Single
room |
Double
room |
Breakfast |
Rate
available until |
****
|
EUR
120
|
EUR
143
|
included |
March
15 , 2006 |
***
|
EUR
110
|
EUR
120
|
included |
March
15 , 2006 |
**
|
EUR
80
|
EUR
90
|
included |
March
15 , 2006 |
Send the enclosed
hotel accommodation form to Iantra Viaggi sas, P.zza Donatori
di Sangue, 5 - 37124 Verona (Italy), Phone +39-045 8303306,
Fax +39-045 8388581, E-mail info@iantra.it
Click for Hotel
Registration Form (PDF)
The deadline for hotel reservation is March 15,
2006. Requests received after this deadline will
be taken into consideration, but accommodation in the chosen
hotel category cannot be guaranteed. Iantra Viaggi will
suggest other suitable accommodations. Iantra Viaggi will
send a confirmation voucher only after receiving the hotel
accommodation form and the payment of the hotel deposit
+ reservation fee. The voucher will specify the name and
the address of the hotel, the amount already paid and the
balance due. Please do not forget to indicate in the form
an e-mail address or fax number where the confirmation can
be sent to. Forms received without the corresponding payment
will not be taken into consideration.
Payment
Hotel Accommodation
For methods of payment, please see hotel accommodation form.
Payment
Registration Fee
Please indicate your name and the payment reference number
0624 on all money transfers.
Congrex will not be responsible for identifying funds transferred
directly into the account when the name of the participant
or invoice number is not mentioned, nor will Congrex accept
charges of bank fees associated with the transfer.
Payment should be made in advance by one of the following
methods:
-
American Express, Visa or Eurocard/Mastercard may be used
for all charges. Please indicate card number and expiry
date on the registration form.
-
Transfer to SEB (Skandinaviska Enskilda Banken), SE-106
40 Stockholm, Sweden, BIC/SWIFT-code: ESSESESS,
Account no. 5936-8253269
IBAN no SE68 5000 0000 05936825-3269
in EUR to Congrex Sweden AB, Attn: WPSBI
-
Banker’s draft, which should be sent together with
the registration form by ordinary mail. The Banker’s
draft should be purchased at your bank and made out in
EUR to Congrex Sweden AB, wpsbi.registration@congrex.se.
Please cross the draft. We are not able to accept personal
cheques, company cheques or Eurocheques. Please send the
banker’s draft to: Congrex Sweden AB, Attn: WPSBI,
P.O. Box 5619, SE-114 86 Stockholm, Sweden.
-
Scandinavian residents may pay by bank or postal giro
transfer.
Bank giro 224-7021, or postal giro 9052-2.
As from 3 weeks before the Conference, Congrex only accepts
credit card as payment. Registrations will be confirmed when
Congrex has received payment. Admission to the Conference
is granted only if Congrex has received the registration fee.
Delegates, who have made late payments, should bring a proof
of payment to the Conference. Failure to produce this on request
gives Congrex the right to charge the amount to your credit
card.
Cancellation
of Registration
Notification of cancellation must be made in writing and
sent to Congrex.
Cancellation of registration will be accepted until March
1, 2006, up to which date the total amount will be refunded
less EUR 50 for administrative expenses. For cancellations
made after March 1, 2006 we regret that no refunds can be
made.
Cancellation
of Hotel Reservation
Cancellations of the hotel accommodation must be sent in
writing to Iantra Viaggi. Cancellations received by April
5, 2006 will be entitled to a complete refund (reservation
fee excluded). There will be no refund for cancellations
received after April 5, 2006.
General
Information
Each participant will receive a name badge upon registration.
For security reasons all participants are requested to wear
their name badge during all the Conference activities.
Currency
The currency in Italy is EUR.
Disclaimer/Liability
The Organising Committee and Congrex Sweden AB accept no
liability for any injuries/losses incurred by participants
and/or accompanying persons, nor loss of, or damage to,
any luggage and/or personal belongings.

The Congrex Group works internationally with subsidiaries
in the Netherlands, the United States and Sweden as well
as licensed partners throughout Europe and Latin America.

Iantra Travel and Events is a young and dynamic company
located in Verona, in Northern Italy. IANTRA is specialised
in incentive trips, car launches, congresses and special
events organisation. Iantra was born in October 1997 by
the will of the Director of the congress and incentive department
of a big Italian company, leader in the organisation of
services and travels on national and international levels.
The company is now formed by a multilingual group of experienced
people, who have been working in this field for more than
15 years.

Founded in 1998, Health Links is a full service event organising
company with a wealth of experience within the health, social
and environmental sectors.
Useful
Addresses
Registration
|
EUFEPS
Secretariat |
Conference
Venue |
Congrex
Sweden AB
Attn: WPSBI
PO Box 5619
SE-114 86 Stockholm, Sweden
Phone +46 8 4596600
Fax +46 8 6619125
Email wpsbi.registration@congrex.se
Website http://www.congrex.com |
Attn:
Annika Nyman
PO Box 1136
SE-111 81 Stockholm, Sweden
Phone +46 8 7235000
Fax +46 8 4113217
Email conferences@eufeps.org
Website www.eufeps.org
|
Facilities
of the GlaxoSmithKline
Via A Fleming 4
IT-37135 Verona
ITALY |
| Hotel
Reservation |
Exhibition
and sponsorship information packages etc. |
|
IANTRA
Viaggi s.a.s.
Piazza Donatori di Sangue, 5
IT-37124 Verona, Italy
Phone +39 045 8303306
Fax +39 045 8388581
Email info@iantra.it
Website http://www.iantra.it |
Health
Links
Attn: Chris Hanney
3rd Floor, Windsor House, 11A High Street
Kings Heath, Birmingham B14 7BB, United Kingdom
Phone +44 208 7496471
Fax +44 121 2483390
Email chrishanney@btclick.com
Website
http://www.health-links.co.uk |
|
|
|