| First
Announcement – April 2009
International Conference
on Pharmacokinetics: Spearheading Advances and Delivering the
Science

View of Lambeth Palace
October
5 • 2009 •
Royal Pharmaceutical Society •
London • United Kingdom
On
the Occasion of
Professor Malcolm Rowland’s 70th Birthday
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This Conference
is
Organised by the Academy of Pharmaceutical Sciences of Great Britain
(APSGB)
and the European Federation for Pharmaceutical Sciences (EUFEPS)
Co-sponsored by the Royal Pharmaceutical Society of Great Britain
(RPSGB)
and the International Pharmaceutical Federation (FIP)
The Conference
will start at 09:00 (registration from 08:00) and close at approximately18:00
– followed by an optional dinner, in the evening.
Scope
& Aim
This one-day conference will highlight and review recent advances
in the field of pharmacokinetics.
The science
of pharmacokinetics has very much become mechanism based through
better fundamental insights into the mechanisms and regulation of
drug absorption, metabolism, transport and excretion. Thus physiologically
based pharmacokinetics (PBPK) is now a relevant and integral part
of research on, and the development of, new drug substances. Well
known experts from all over the globe will address recent scientific
advances and their impact on drug research, drug development, drug
regulation and education.
Professor
Malcolm Rowland has been contributing to the field of pharmacokinetics
in a most scholarly and inspiring manner for more than 40 years.
Through his distinctive and clear publications, lectures, workshops
and textbooks there is hardly anybody working in the field of pharmacokinetics
that will not be familiar with his name and fame. Therefore, this
conference is being organised to pay tribute to his tremendous contributions
to pharmacokinetics on the occasion of his 70th birthday.
Who
should attend?
This conference
should be attended by anyone interested in the most recent advances
in the field of pharmacokinetics, working in academia or the pharmaceutical
industry or drug regulation. Within a condensed one-day programme
the major highlights will be presented by the best internationally
renowned experts in the field.
Scientific
and Planning Committee
Leslie Z. Benet, University of California, San
Francisco CA, USA
Douwe D. Breimer (Chair), Leiden University, Leiden, The Netherlands
Daan J.A. Crommelin, Utrecht University and Dutch Top Institute
Pharma, Utrecht and Leiden, The Netherlands
Eddie French, Pfizer Global R&D, Sandwich, United Kingdom
Jayne Lawrence, Royal Pharmaceutical Society of Great Britain,
London, United Kingdom
Hans H. Linden, EUFEPS Central Office, Stockholm, Sweden
Kamal K. Midha, FIP, The Hague, The Netherlands
Tony Moffat, The School of Pharmacy, University of London,
London, United Kingdom
Carl C. Peck, University of California, San Francisco CA, USA
Geoff Tucker, University of Sheffield, Sheffield, United Kingdom
Yuichi Sugiyama, University of Tokyo, Tokyo, Japan
Preliminary
Programme
| Session
1 |
Kinetics
of drug transport
Chair: Kamal K. Midha, FIP, The Hague, The
Netherlands |
| 09:00
– 09:10 |
Malcolm
Rowland and the International Pharmaceutical Federation (FIP)
Kamal K. Midha, FIP, The Hague, The Netherlands |
| 09:10
– 09:35 |
Clearance (née
Rowland) concepts: A downdate and update
Leslie Z. Benet, University of California, San Francisco
CA, USA |
| 09:35
– 10:00 |
Application of PBPK
modelling to drugs showing transporter-mediated distribution
and clearance in human
Yuichi Sugiyama, University of Tokyo, Tokyo, Japan |
| 10:00
– 10:25 |
Drug transport –
structure relationships
Mike S. Roberts, University of South Australia, School
of Medicine, University of Queensland, Brisbane, Australia |
| 10:25
– 10:55 |
Coffee Break |
| Session
2 |
Kinetics
of Drug Metabolism
Chair: Douwe D. Breimer, Leiden University,
Leiden, The Netherlands |
| 10:55
– 11:20 |
From
PpH to PBPK
Geoffrey T. Tucker, University of Sheffield, Sheffield,
United Kingdom |
| 11:20
– 11:45 |
PBPK modelling of
metabolites
K. Sandy Pang, University of Toronto, Toronto, Canada
|
| 11:45
– 12:10 |
CAPKR (Centre for
Applied Pharmacokinetic Research) – the Manchester Hub
for DMPK
Brian Houston, University of Manchester, Manchester,
United Kingdom |
| 12:10
– 14:00 |
Lunch |
| Session
3 |
Drug regulation
and the pharmaceutical industry
Chair: Daan J.A. Crommelin, Utrecht University
and Dutch Top Institute Pharma, Utrecht and Leiden, The Netherlands
|
| 14:00
– 14:10 |
Malcolm
Rowland and EUFEPS
Daan J.A. Crommelin, Utrecht University and
Dutch Top Institute Pharma, Utrecht and Leiden, The Netherlands |
| 14:10
– 14:35 |
Quantitative clinical
pharmacology has transformed drug regulation
Carl C. Peck, University of California, San Francisco
CA, USA |
| 14:35
– 15:00 |
PBPK modelling:
Extending Malcolm Rowland’s concepts to anatomy and drug
development
Donald R. Stanski, Novartis Pharma, Basel, Switzerland |
| 15:00
– 15:25 |
MEDicines EVALuation:
Quantitative science in early clinical development
Steve Toon, SimCYP, Sheffield, United Kingdom |
| 15:25
– 15:55 |
Coffee Break |
| Session
4 |
Education
Chair: Tony Moffat, The School of Pharmacy,
University of London, London, United Kingdom |
| 15:55
– 16:05 |
Malcolm
Rowland and APSGB
Eddie French, Academy of Pharmaceutical Sciences of
Great Britain, Leicester, United Kingdom |
| 16:05
– 16:30 |
Teaching the World
Jeffrey K. Aronson, British Pharmacological Society,
London, United Kingdom |
| 16:30
– 16:55 |
Biography of a Dean
– translating science into practice
Peter Noyce, University of Manchester, Manchester,
United Kingdom |
| 16:55
– 17:15 |
Education of health
professionals and pharmaceutical
Scientists (video presentation)
Thomas N. Tozer, University of California, San Francisco
CA, USA |
| 17:15
– 18:00 |
Final comments by
Malcolm Rowland, University of Manchester, Manchester,
United Kingdom |
| 18:30 |
Reception |
| Evening |
Celebration Dinner
(optional) |
Language
English will be the language of the Conference. No simultaneous
translation will be provided.
Conference
Venue & Location
Royal Pharmaceutical Society of Great Britain, 1 Lambeth High Street,
SE1 7JN London, United Kingdom.
Further information on
the location of the venue is available on the RPSGB
website at: http://www.rpsgb.org/pdfs/rpsgbmap.pdf
Registration
& Accommodation
To register to this Conference, fill out the Registration Form and
send it to the to the address indicated in the Form. As the Form
will be received and the registration confirmed recommendations
of hotels to contact in the area will be provided. .
Click for
Conference Registration Form
Additional
Information
For more or update information, see this Conference Website, or
contact:
APS
840 Melton Road, Thurmaston, Leicester LE4 8BN
United Kingdom
Tel +44 116 2692299
Fax +44 116 2640141
Email info@apsgb.org
Website http://www.apsgb.co.uk
EUFEPS
PO Box 1136, SE-111 81 Stockholm, Sweden
Tel +46 8 7601050
Fax +46 8 4113217
Email conferences@eufeps.org
Website http://www.eufeps.org
Malcolm
Rowland
Biographical Sketch
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Malcolm
Rowland is Professor Emeritus and former Dean, School of Pharmacy
and Pharmaceutical Sciences, and member and former director
(1996-2000), Centre for Applied Pharmacokinetic Research,
University of Manchester. He is a Member, Governing Board,
EU Network of Excellence in Biosimulation (Biosim); adjunct
professor, University of California San Francisco; advisor
to EMEA; Founder member of NDA Partners, and was President,
EUFEPS (European Federation for Pharmaceutical Sciences, 1996-2000)
and Vice-President FIP (International Pharmaceutical Federation,
2001-2008). He received his degree in Pharmacy and PhD, University
of London, and was on faculty, School of Pharmacy, University
of California San Francisco (1967-75) before taking up a professorship
at Manchester.
He has
been awarded honorary doctorate degrees from the University
of Poitiers (France) and Uppsala (Sweden), and Honorary Membership,
Royal College of Physicians (London). He received the 2007
ACCP Distinguished Investigator Award, the Millennial Pharmaceutical
Scientist Award (FIP BPS, 2000), and 1994 AAPS Research Achievement
Award in Pharmacokinetics, Pharmacodynamics and Drug Metabolism.
He has been awarded fellowship of the Academy of Medical Sciences,
ACCP (Hon), the Royal Pharmaceutical Society of Great Britain,
AAPS, and the Institute of Mathematics. In 2002 he was rated
among the top 200 most cited pharmacologists worldwide by
the Institute of Scientific Information.
His
main research interest is physiologically based pharmacokinetics
and its application to drug discovery, development and use.
He is author of over 300 scientific articles, and co-author
with Thomas Tozer of the textbooks Clinical Pharmacokinetics:
Concepts and Applications, and Introduction to Pharmacokinetics
and Pharmacodynamics. He was editor of the Journal of
Pharmacokinetics and Pharmacodynamics (Formerly Journal of
Pharmacokinetics and Biopharmaceutics; 1973-2007), and has
established European and U.S.A. pharmacokinetic workshops.
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Speakers,
Chairpersons and Affiliations
Dr Jeffrey K. Aronson
President, British Pharmacological Society, Department of Clinical
Pharmacology, University of Oxford, Oxford, United Kingdom
Leslie Z. Benet
Professor at the University of California, San Francisco CA, USA
Douwe D. Breimer
Professor of Pharmacology at Leiden University, and Former Rector
Magnificus & President of the Leiden University, Leiden, The
Netherlands
Daan J.A. Crommelin
President of the European Federation for Pharmaceutical Sciences
(EUFEPS), Professor of Pharmaceutics at the University of Utrecht,
Utrecht, and Scientific Director of the Dutch Top Institute Pharma,
Leiden, The Netherlands
Dr Eddie French
Chair, Academy of Pharmaceutical Sciences of Great Britain, Leicester,
and Director, Pharmaceutical Sciences at Pfizer Global R&D,
Sandwich, United Kingdom
Brian Houston
Professor of Drug Metabolism and Pharmacokinetics at the School
of Pharmacy & Pharmaceutical Sciences, University of Manchester,
Manchester United Kingdom
Kamal K. Midha
Adjunct Professor, President of the International Pharmaceutical
Federation (FIP)
Anthony Moffat
Emeritus Professor, The School of Pharmacy, University of London,
London, United Kingdom
Peter Noyce CBE
Professor of Pharmacy Practice, School of Pharmacy & Pharmaceutical
Sciences, University of Manchester, Manchester, United Kingdom
K. Sandy Pang
Professor at the Department of Pharmaceutical Sciences, University
of Toronto, Toronto, Canada
Carl Peck
Founder and Chairman of NDA Partners and Adjunct Professor at the
Center for Drug Development Science, School of Pharmacy, University
of California, San Francisco CA, USA
Mike S. Roberts
Professor of Therapeutics & Pharmaceutical Sciences, University
of South Australia and Director of the Therapeutics Research Unit
at the School of Medicine, University of Queensland, Brisbane, Australia
Donald R. Stanski
Global Head Modelling and Simulation at Novartis Pharma, Basel,
Switzerland, and Emeritus Professor of Anaesthesia, Stanford University,
Stanford CA, USA
Yuichi Sugiyama
Professor at the Graduate School of Pharmaceutical Sciences, The
University of Tokyo, Tokyo, Japan
Dr Steve Toon
Executive Director SimCYP Limited, Sheffield, United Kingdom
Thomas N. Tozer
Emeritus Professor of Biopharmaceutical Sciences and Pharmaceutical
Chemistry, San Francisco CA, and Adjunct Professor of Pharmacology
at the University of California, San Diego CA, USA
Geoffrey T. Tucker
Emeritus Professor of Clinical Pharmacology, University of Sheffield,
and Chairman, SimCYP Limited, Sheffield, United Kingdom
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