First Announcement – April 2009

International Conference on Pharmacokinetics: Spearheading Advances and Delivering the Science


View of Lambeth Palace

October 5 2009 Royal Pharmaceutical Society London United Kingdom

On the Occasion of
Professor Malcolm Rowland’s 70th Birthday

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This Conference is
Organised by the Academy of Pharmaceutical Sciences of Great Britain (APSGB)
and the European Federation for Pharmaceutical Sciences (EUFEPS)
Co-sponsored by the Royal Pharmaceutical Society of Great Britain (RPSGB)
and the International Pharmaceutical Federation (FIP)

The Conference will start at 09:00 (registration from 08:00) and close at approximately18:00 – followed by an optional dinner, in the evening.

Scope & Aim
This one-day conference will highlight and review recent advances in the field of pharmacokinetics.

The science of pharmacokinetics has very much become mechanism based through better fundamental insights into the mechanisms and regulation of drug absorption, metabolism, transport and excretion. Thus physiologically based pharmacokinetics (PBPK) is now a relevant and integral part of research on, and the development of, new drug substances. Well known experts from all over the globe will address recent scientific advances and their impact on drug research, drug development, drug regulation and education.

Professor Malcolm Rowland has been contributing to the field of pharmacokinetics in a most scholarly and inspiring manner for more than 40 years. Through his distinctive and clear publications, lectures, workshops and textbooks there is hardly anybody working in the field of pharmacokinetics that will not be familiar with his name and fame. Therefore, this conference is being organised to pay tribute to his tremendous contributions to pharmacokinetics on the occasion of his 70th birthday.

Who should attend?
This conference should be attended by anyone interested in the most recent advances in the field of pharmacokinetics, working in academia or the pharmaceutical industry or drug regulation. Within a condensed one-day programme the major highlights will be presented by the best internationally renowned experts in the field.

Scientific and Planning Committee
Leslie Z. Benet, University of California, San Francisco CA, USA
Douwe D. Breimer
(Chair), Leiden University, Leiden, The Netherlands
Daan J.A. Crommelin,
Utrecht University and Dutch Top Institute Pharma, Utrecht and Leiden, The Netherlands
Eddie French,
Pfizer Global R&D, Sandwich, United Kingdom
Jayne Lawrence,
Royal Pharmaceutical Society of Great Britain, London, United Kingdom
Hans H. Linden,
EUFEPS Central Office, Stockholm, Sweden
Kamal K. Midha,
FIP, The Hague, The Netherlands
Tony Moffat,
The School of Pharmacy, University of London, London, United Kingdom
Carl C. Peck,
University of California, San Francisco CA, USA
Geoff Tucker,
University of Sheffield, Sheffield, United Kingdom
Yuichi Sugiyama,
University of Tokyo, Tokyo, Japan

Preliminary Programme

Session 1 Kinetics of drug transport
Chair: Kamal K. Midha, FIP, The Hague, The Netherlands
09:00 – 09:10 Malcolm Rowland and the International Pharmaceutical Federation (FIP)
Kamal K. Midha, FIP, The Hague, The Netherlands
09:10 – 09:35 Clearance (née Rowland) concepts: A downdate and update
Leslie Z. Benet, University of California, San Francisco CA, USA
09:35 – 10:00 Application of PBPK modelling to drugs showing transporter-mediated distribution and clearance in human
Yuichi Sugiyama, University of Tokyo, Tokyo, Japan
10:00 – 10:25 Drug transport – structure relationships
Mike S. Roberts, University of South Australia, School of Medicine, University of Queensland, Brisbane, Australia
10:25 – 10:55 Coffee Break

Session 2 Kinetics of Drug Metabolism
Chair: Douwe D. Breimer, Leiden University, Leiden, The Netherlands
10:55 – 11:20 From PpH to PBPK
Geoffrey T. Tucker, University of Sheffield, Sheffield, United Kingdom
11:20 – 11:45 PBPK modelling of metabolites
K. Sandy Pang, University of Toronto, Toronto, Canada
11:45 – 12:10 CAPKR (Centre for Applied Pharmacokinetic Research) – the Manchester Hub for DMPK
Brian Houston, University of Manchester, Manchester, United Kingdom
12:10 – 14:00 Lunch

Session 3 Drug regulation and the pharmaceutical industry
Chair: Daan J.A. Crommelin, Utrecht University and Dutch Top Institute Pharma, Utrecht and Leiden, The Netherlands
14:00 – 14:10 Malcolm Rowland and EUFEPS
Daan J.A. Crommelin, Utrecht University and
Dutch Top Institute Pharma, Utrecht and Leiden, The Netherlands
14:10 – 14:35 Quantitative clinical pharmacology has transformed drug regulation
Carl C. Peck, University of California, San Francisco CA, USA
14:35 – 15:00 PBPK modelling: Extending Malcolm Rowland’s concepts to anatomy and drug development
Donald R. Stanski, Novartis Pharma, Basel, Switzerland
15:00 – 15:25 MEDicines EVALuation: Quantitative science in early clinical development
Steve Toon, SimCYP, Sheffield, United Kingdom
15:25 – 15:55 Coffee Break

Session 4 Education
Chair: Tony Moffat, The School of Pharmacy, University of London, London, United Kingdom
15:55 – 16:05 Malcolm Rowland and APSGB
Eddie French, Academy of Pharmaceutical Sciences of Great Britain, Leicester, United Kingdom
16:05 – 16:30 Teaching the World
Jeffrey K. Aronson, British Pharmacological Society, London, United Kingdom
16:30 – 16:55 Biography of a Dean – translating science into practice
Peter Noyce, University of Manchester, Manchester, United Kingdom
16:55 – 17:15 Education of health professionals and pharmaceutical
Scientists (video presentation)
Thomas N. Tozer, University of California, San Francisco CA, USA
17:15 – 18:00 Final comments by
Malcolm Rowland, University of Manchester, Manchester, United Kingdom
18:30 Reception
Evening Celebration Dinner (optional)

Language
English will be the language of the Conference. No simultaneous translation will be provided.

Conference Venue & Location
Royal Pharmaceutical Society of Great Britain, 1 Lambeth High Street, SE1 7JN London, United Kingdom.

Further information on the location of the venue is available on the RPSGB website at: http://www.rpsgb.org/pdfs/rpsgbmap.pdf

Registration & Accommodation
To register to this Conference, fill out the Registration Form and send it to the to the address indicated in the Form. As the Form will be received and the registration confirmed recommendations of hotels to contact in the area will be provided. .

Click for Conference Registration Form

Additional Information
For more or update information, see this Conference Website, or contact:

APS
840 Melton Road, Thurmaston, Leicester LE4 8BN
United Kingdom
Tel +44 116 2692299
Fax +44 116 2640141
Email info@apsgb.org
Website http://www.apsgb.co.uk

EUFEPS
PO Box 1136, SE-111 81 Stockholm, Sweden
Tel +46 8 7601050
Fax +46 8 4113217
Email conferences@eufeps.org
Website http://www.eufeps.org

Malcolm Rowland
Biographical Sketch

Malcolm Rowland is Professor Emeritus and former Dean, School of Pharmacy and Pharmaceutical Sciences, and member and former director (1996-2000), Centre for Applied Pharmacokinetic Research, University of Manchester. He is a Member, Governing Board, EU Network of Excellence in Biosimulation (Biosim); adjunct professor, University of California San Francisco; advisor to EMEA; Founder member of NDA Partners, and was President, EUFEPS (European Federation for Pharmaceutical Sciences, 1996-2000) and Vice-President FIP (International Pharmaceutical Federation, 2001-2008). He received his degree in Pharmacy and PhD, University of London, and was on faculty, School of Pharmacy, University of California San Francisco (1967-75) before taking up a professorship at Manchester.

He has been awarded honorary doctorate degrees from the University of Poitiers (France) and Uppsala (Sweden), and Honorary Membership, Royal College of Physicians (London). He received the 2007 ACCP Distinguished Investigator Award, the Millennial Pharmaceutical Scientist Award (FIP BPS, 2000), and 1994 AAPS Research Achievement Award in Pharmacokinetics, Pharmacodynamics and Drug Metabolism. He has been awarded fellowship of the Academy of Medical Sciences, ACCP (Hon), the Royal Pharmaceutical Society of Great Britain, AAPS, and the Institute of Mathematics. In 2002 he was rated among the top 200 most cited pharmacologists worldwide by the Institute of Scientific Information.

His main research interest is physiologically based pharmacokinetics and its application to drug discovery, development and use. He is author of over 300 scientific articles, and co-author with Thomas Tozer of the textbooks Clinical Pharmacokinetics: Concepts and Applications, and Introduction to Pharmacokinetics and Pharmacodynamics. He was editor of the Journal of Pharmacokinetics and Pharmacodynamics (Formerly Journal of Pharmacokinetics and Biopharmaceutics; 1973-2007), and has established European and U.S.A. pharmacokinetic workshops.

Speakers, Chairpersons and Affiliations

Dr Jeffrey K. Aronson
President, British Pharmacological Society, Department of Clinical Pharmacology, University of Oxford, Oxford, United Kingdom

Leslie Z. Benet
Professor at the University of California, San Francisco CA, USA

Douwe D. Breimer
Professor of Pharmacology at Leiden University, and Former Rector Magnificus & President of the Leiden University, Leiden, The Netherlands

Daan J.A. Crommelin
President of the European Federation for Pharmaceutical Sciences (EUFEPS), Professor of Pharmaceutics at the University of Utrecht, Utrecht, and Scientific Director of the Dutch Top Institute Pharma, Leiden, The Netherlands

Dr Eddie French
Chair, Academy of Pharmaceutical Sciences of Great Britain, Leicester, and Director, Pharmaceutical Sciences at Pfizer Global R&D, Sandwich, United Kingdom

Brian Houston
Professor of Drug Metabolism and Pharmacokinetics at the School of Pharmacy & Pharmaceutical Sciences, University of Manchester, Manchester United Kingdom

Kamal K. Midha
Adjunct Professor, President of the International Pharmaceutical Federation (FIP)

Anthony Moffat
Emeritus Professor, The School of Pharmacy, University of London, London, United Kingdom

Peter Noyce CBE
Professor of Pharmacy Practice, School of Pharmacy & Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom

K. Sandy Pang
Professor at the Department of Pharmaceutical Sciences, University of Toronto, Toronto, Canada

Carl Peck
Founder and Chairman of NDA Partners and Adjunct Professor at the Center for Drug Development Science, School of Pharmacy, University of California, San Francisco CA, USA

Mike S. Roberts
Professor of Therapeutics & Pharmaceutical Sciences, University of South Australia and Director of the Therapeutics Research Unit at the School of Medicine, University of Queensland, Brisbane, Australia

Donald R. Stanski
Global Head Modelling and Simulation at Novartis Pharma, Basel, Switzerland, and Emeritus Professor of Anaesthesia, Stanford University, Stanford CA, USA

Yuichi Sugiyama
Professor at the Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

Dr Steve Toon
Executive Director SimCYP Limited, Sheffield, United Kingdom

Thomas N. Tozer
Emeritus Professor of Biopharmaceutical Sciences and Pharmaceutical Chemistry, San Francisco CA, and Adjunct Professor of Pharmacology at the University of California, San Diego CA, USA

Geoffrey T. Tucker
Emeritus Professor of Clinical Pharmacology, University of Sheffield, and Chairman, SimCYP Limited, Sheffield, United Kingdom



The European Federation for Pharmaceutical Sciences – EUFEPS
SE-175 72 Järfälla (Stockholm) Sweden
Tel +46 8 50582040   Fax +46 8 4113217   Email secretariat@eufeps.org