Taking PAT to the Next Level

May 5-6 2010 Hotel Puijonsarvi Kuopio Finland


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Invitation to Join
This is to invite you to submit abstracts and attend the fourth pan-European Science Conference on Process Analytical Technology (PAT), building on the success of the previous EuPAT meetings. It will be held on May 5-6, 2010, in Kuopio, Finland, and organised back-to-back to a Graduate School Course “Process analytical aspects of biopharmaceutical manufacturing”, held on May 4, 2009, in Kuopio. The attendees of EuPAT4 are welcome to register to the graduate school course and vice versa.

The EuPAT Conference Series is a unique forum for scientists and engineers, encouraging and promoting progress in science behind PAT and strengthening the interdisciplinary scientific discussion that bridges between the various fields underpinning PAT.

Session Topics of EuPAT4
The topic of EuPAT4 – Taking PAT to the Next Level – underlines the importance of comprehensive process understanding. At this event special attention will be paid to following topics:
• PAT in solid dosage form processing
• Novel measurement technologies
• Modelling and simulation
• PAT in bioactive production and downstream processing

Posters and Podium Presentations
In addition to the podium lectures from recognised leaders in the field, PhD students are given the opportunity to present their latest advancements in PAT science. Participants are encouraged to submit abstracts for poster presentations, whilst selected students will be invited to give podium lectures alongside the keynote speakers.

Abstract Submission
Abstracts should be submitted as email attachment in Word format to secretariat@eufeps.org by March 15, 2010.

The abstract, up to one page A4, should be typed single-spaced (12 pt Times Roman font or equivalent, 2.5 cm margins, page size A4) and should include the title, authors, their affiliations and addresses. Please indicate which EuPAT4 session topic best suits the abstract.

The selection of oral presentations and poster presentations will be based on the review of the up to 1-page abstracts (incl. figures) by the Scientific & Planning Committee.

EuPAT4 Scientific & Planning Committee
Staffan Folestad, Mölndal and Göteborg, Sweden (Chair)
Jukka Rantanen, Copenhagen, Denmark
Thomas De Beer, Ghent, Belgium
Buket Aksu, Istanbul, Turkey
Joao Almeida Lopes, Porto, Portugal
Marcel De Matas, Bradford, United Kingdom
Jarkko Ketolainen, Kuopio, Finland
Gerd Kleinschmidt, Frankfurt, Germany
Hans H. Lindén, Stockholm, Sweden
Wim Oostra, Oss, The Netherlands
Jaakko Aaltonen, Kuopio, Finland

Important Dates

Abstract submission Deadline
March 15, 2010
Early-bird Registration Deadline
March 15, 2010

Registration
To register to the EuPAT4, access the registration and payment online form.
Click here for registration online.

The registration will be complete after payment.

Fee Structure (VAT 22 % will be added as applicable; see online registration form)
Industry
Early Member
€ 600
Early Standard
€ 650
Late Member
€ 700
Late Standard
€ 850
Academy/Regulatory
Early Member
€ 350
Early Standard
€ 400
Late Member
€ 450
Late Standard
€ 500
Student
Early
€ 200
 
Late
€ 300


To register to the Graduate school course see the information on the Graduate School website (http://www.uku.fi/farmasia/tutkijakoulu/english/
BioPAT_Kuopio_I.pdf
)

Accommodation
For accommodation, special rate rooms have been blocked at the Sokos Hotel Puijonsarvi
Minna Canthin katu 16
FI-70100 Kuopio, Finland
Tel +358 17 1922000
Fax +358 17 1922001
email: sales.kuopio@sokoshotels.fi
To make use of the reduced room rate, do not forget to indicate discount code ”EuPAT”.

Location and Venue
Kuopio is a modern, developing centre of economic life in Eastern Finland, where the University plays an important role. It is also the home of acknowledged health and well-being expertise. Access is easy by air, on a connecting flight from Helsinki. The venue, Sokos Hotel Puijonsarvi attracts both business and leisure travellers, located right in the Centre of Kuopio (www.sokoshotels.fi/en/hotels/kuopio/).

Additional Information
Please contact:
EUFEPS Meetings and Events
SE-175 72 Jarfalla (Stockholm) Sweden
Tel +46 8 7601050
Fax +46 8 4113217
Email conferences@eufeps.org
http://www.uku.fi/farmasia/tutkijakoulu/english/
BioPAT_Kuopio_I.pdf

On the EuPAT Series
The EuPAT Conference Series is a unique forum for scientists and engineers, encouraging and promoting progress in science behind PAT and strengthening the interdisciplinary scientific discussion that bridges between the various fields underpinning PAT. The focus of it is on scientific progress underpinning Innovative
Manufacturing Control and Quality by Design. New findings and results from scientific research and technology development are discussed in the four areas that constitute the cornerstones of sessions of the EuPAT Conferences; Process Informatics; Process Modelling and Understanding; Advanced Process Sensors; and PAT Based Control and Process Integration.

EUFEPS Network on PAT
Powering Science Based Process Understanding and Quality-by-Design for Medicines, the Network is there to focus on PAT (Process Analytical Technology and underpinning sciences), create and maintain a unique and effective forum to encourage and improve collaboration, actively contribute to education and training, and to promote innovation in relevant sciences – all to power science based process understanding and Quality-by-Design for medicines. All scientists involved in PAT are more than welcome to become a member of the EUFEPS Network on PAT (www.eufeps.org – Network and Networking).

EuPAT4 Preliminary Program

Wednesday, May 5, 2010, 09:30-17:30

Welcome, Introduction and Opening Remarks

QbD and PAT - a Status Report
Prof Fernando J. Muzzio, Rutgers University, NJ, USA
Session: PAT in bioactive production and downstream processing

Near-Infrared as a Biotech PAT/QbD Tool
Dr Emil Ciurczak, Cadrai Technology Group, New York, NY, USA

Process Control of the Freeze-drying Process of a Protein Formulation
Dr Thomas De Beer, Ghent University, Ghent, Belgium

Quality by Design for Freeze-Drying of Biopharmaceuticals Using Advanced Process Analytical Technology
Dr Henning Gieseler, University of Erlangen, Germany

A Roller-Coaster Ride towards In-Line Measurement of Protein Aggregates
Prof. Robert T. Forbes, University of Bradford, UK

Selected oral contributions
Session: Modelling and simulation

Mechanistic Modelling and Mechanistic Sensors - Towards the Ultimate Understanding in Multiphase Processing
Prof. Staffan Folestad, AstraZeneca and Chalmers University of Technology, Mölndal and Göteborg, Sweden

Modelling Powder Processing: Compaction and Powder Flow
Dr Göran Frenning, Uppsala University, Uppsala, Sweden

Exploratory Chemical Imaging Made Easy: Matched Spectral Filtering and Chemometrics
Dr Pekka Teppola, VTT Optical Instrumentation, Finland

Selected oral contributions
Reception at Kuopio City Hall 18:00

Thursday, May 6, 2010, 09:00-16:00

Welcome and Opening of Day Two

Session: PAT in solid dosage form processing

Advanced Real-time Image-based Control of Pharmaceutical Granulation Processes
Prof. Niklas Sandler, Åbo Akademi University, Turku, Finland

Non-invasive online measurements of coating thickness and density of individual tablets in real time during production scale processing using terahertz pulsed imaging
Dr Axel Zeitler, University of Cambridge, UK

Selected oral contributions
Session: Novel measurement technologies

Regulatory Framework to Process Understanding – Mission: Impossible?
Prof. Jukka Rantanen, University of Copenhagen, Denmark

Electrical tomography techniques as PAT tools
Dr Lasse Heikkinen, University of Eastern Finland, Kuopio, Finland

Selected oral contributions
Closing Remarks


Founded in 1991, the mission of EUFEPS is to advance excellence in the pharmaceutical sciences and innovative drug research, and to represent the interests of scientists engaged in drug research and development, drug regulation and drug policymaking. Currently, EUFEPS links 24 Member Societies in 24 European countries. It has, in adition, around 600 Individual Members.


Founded in 1980, ISPE has worldwide headquarters in Tampa, Florida; an Asia Pacific office in Singapore; a European office in Brussels, Belgium; and Affiliates and Chapters in 19 countries around the world.


The University of Eastern Finland is an amalgamation of the University of Kuopio and the University of Joensuu, in joint and full operation from January 1, 2010. There are three campuses - in Kuopio, in Joensuu and in Savonlinna. It combines already strong areas of research and high quality education. It forms the basis for expanded multidisciplinary developments.



The European Federation for Pharmaceutical Sciences – EUFEPS
SE-175 72 Järfälla (Stockholm) Sweden
Tel +46 8 50582040   Fax +46 8 4113217   Email secretariat@eufeps.org