EUFEPS Conference onDrug Transporters:
A unique discussion
forum for scientists from the pharmaceutical industry, regulatory
agencies, and academic institutions. |
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Download the 2nd Announcement |
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Download the Conference Registration Form |
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Download the Hotel Registration Form |
Scope
and aim
This three-day Conference will be devoted to recent advances
in the study of membrane transporters with respect to bioavailability
and drug disposition in the body. It will cover an integrated
view of drug absorption, distribution, metabolism and excretion
as well as interactions during these processes and their clinical
implications. A particular aim of the Conference is to critically
review in vitro and in vivo methodologies
that are used to investigate the role of membrane transporters
in pharmacokinetics. Ample meeting time will be devoted to round-table
discussions in addition to the invited state-of-the-art lectures.
The organisers envision this conference as an endeavour in scientific
communication and integration. It is an AAPS-EUFEPS Exchange
event, following on from the AAPS Workshop on Drug Transporters
in February 2003.
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Advanced methodologies to study drug transport: Assessment of the state-of-art
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Renal, hepatic, intestinal and placental transporters: Expression, regulation and substrate specificity
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Prediction of in vivo transport from in vitro and animal data
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Transport-metabolism relationship in drug disposition
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Clinical implications of transporters: Functional polymorphisms, drug delivery and drug interactions
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Reports on outcomes of group discussions
Format
& Preliminary Programme
Using a similar format to previous EUFEPS conferences, key segments
of the process are broken down into a number of sessions, each
with lectures and discussions. In the round-table discussions,
the topics will be discussed further in smaller groups and supplementary
information added from the participants of the session. The discussion
leaders and co-chairs will present the interactive discussion
summary reports on the third afternoon of the Conference.
Nyhavn,
Copenhagen.
Scientific
Planning Committee
Chairman: Hans Lennernäs, Uppsala SE
Co-Chairs: Dirk KF Meijer, Groningen NL and Jashvant
D Unadkat, Seattle WA USA
Other Members: Michel Lemaire, Basel CH, Andrew D
Ayrton, Welwyn UK and Yuichi Sugiyama, Tokyo JP
Exhibition
Information
Companies are invited to exhibit at the Conference. For information
on layout, costs etc., as well as an exhibition registration form,
please contact the EUFEPS Secretariat.
Call
for Posters
Scientific contributions relating to the conference topic will
certainly be welcome and considered for poster presentation. Abstracts
should be submitted to the EUFEPS Secretariat (for address, see
below), both as an email attachment and as a hard copy, before
March 1, 2004.
Clic for Editorial
instructions.
Language
English will be the language of the Conference. No simultaneous
translation will be provided.
Organiser
EUFEPS was founded in 1991. Its mission is to advance excellence
in the pharmaceutical sciences and innovative drug research, and
to represent the interests of scientists engaged in drug research
and development, drug regulation and drug policymaking. Currently,
it links scientific societies and associations in 25 European
countries and there are 500 individual members of EUFEPS.
Preliminary Programme
Welcome,
Introduction and Opening Remarks
Ole J Bjerrum, EUFEPS President, Copenhagen DK
Hans Lennernäs, Conference Chairman, Uppsala SE
Session I: Advanced methodologies
to study drug transport: Assessment of the state-of-art
Session Leader: Michel Lemaire, Basel CH
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Using PET to image transport activity at the blood-brain and the placental barrier in human and non-human primates Jashvant D Unadkat, Seattle WA USA
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Loc-I-Gut technique for intestinal and biliary excretion studies in vivo in humans
Hans Lennernäs, Uppsala SE -
Isolated perfused liver and hepatocyte sandwich culture to predict biliary excretion
Kim LR Brouwer, Chapel Hill NC USA -
Transport of drugs into the brain: the role of permeability and efflux transporters
Joseph W Polli, Research Triangle Park NC USA -
Human tissues in pharmacokinetic screening: Slices, cells and cell fragments and their predictive values
Geny MM Groothuis, Groningen NL -
Intestinal, renal and hepatic cell lines for ADME prediciton
Johan E Karlsson, Gothenburg SE -
Interactive discussion of this issue in smaller groups
Co-chairs: Andrew D Ayrton, Hertfordshire UK and Michel Lemaire, Basel CH
Session
II: Renal, hepatic, intestinal and placental transporters:
Expression regulation and substrate specificity
Session Leader: Jashvant D Unadkat, Seattle WA USA
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Double-transfectant cell lines for pharmaceutical compound profiling: A novel model for hepatobiliary elimination
Werner Kramer, Frankfurt DE -
Structure transport relationship studies of cationic drugs
Dirk KF Meijer, Groningen NL -
Renal and placental transporters
Frans GM Russel, Nijmegen NL -
Cardiac expression of drug transport
Heyo K Kroemer, Greifswald DE -
Interactive discussion of this issue in smaller groups
Co-chairs: Kim LR Brouwer, Chapel Hill NC USA and Jashvant D Unadkat, Seattle WA USA
Poster Session
(Drinks and snacks)
Session
III: Prediction of in vivo
transport from in vitro animal data
Session
Leader: Geoffrey T Tucker, Sheffield UK
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Membrane transport: A crucial factor in drug discovery and delivery
Akira Tsuji, Kanazawa JP -
The role of P-glycoprotein in drug-drug interactions: Clinical implications
Jiunn Lin, West Point PA USA -
The role of hepatic transporters in pharmacokinetics
Karin Fattinger, Zürich DE -
Transporters at the blood-brain barrier and blood-CSF barrier
Jean-Francois Ghersi-Egea, Lyon FR -
Interactive discussion of this issue in smaller groups
Co-chairs: Geoffrey T Tucker, Sheffield UK and Dirk KF Meijer, Groningen NL
Session
IV: Transport-metabolism relationship
in drug disposition
Session
Leader: Malcolm Rowland, Manchester UK
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Impact of transporters in the intestine on drug bioavailability and pharmacokinetics
Leslie Z Benet, San Francisco CA USA -
The role of transporters in drug disposition
Paul Morgan, Sandwich UK -
An integrated approach to study hepatic drug extraction
K Sandy Pang, Toronto CA -
An integrated view on cellular transport and metabolism and its importance for clinical pharmacokinetics
Geoffrey T Tucker, Sheffield UK -
Interactive discussion of this issue in smaller groups
Co-chairs: Paul Morgan, Sandwich UK and Malcolm Rowland, Manchester UK
(Drinks and snacks)
Easy to tour the streets of Copenhagen.
Session
V: Clinical implications of transporters:
Functional polymorphisms, drug delivery and drug interactions
Session
Leader: Leslie Z Benet, San Francisco CA USA
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Functional polymorphisms and clinical implications of MDRI Michel Eichelbaum, Stuttgart DE
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The impact of OATP transporters for human pharmacokinetics and drug interactions
Dennis W Schneck, Wilmington DE USA -
Transporters and enzymes for nucleoside prodrug delivery
Gordon L Amidon, Ann Arbor MI USA -
Some regulatory aspects on drug transport interactions
Marie Gårdmark, Uppsala SE -
Interactive discussion of this issue in smaller groups
Co-chairs: Gordon L Amidon, Ann Arbor MI USA and Leslie Z Benet, San Francisco CA USA
Session
VI: Report and conclusions
from each interactive discussion session
Concluding
remarks
Hans Lennernäs, Conference Chairman, Uppsala
SE
Dirk KF Meijer, Groningen NL
Jashvant D Unadkat, Seattle WA USA
Rådhusplatsen,
Copenhagen.
Location
The Conference will take place at the Moltke’s Palace, Dronningens
Tvaergade 2, Copenhagen K, DK-1302 Denmark. Phone: +45 3314 8066,
Fax: +45 3315 9106.
How
to get there
To reach the Moltke’s Palace from the Airport:
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Taxi, travelling time around 15 minutes at an approximate cost of DKK 160
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Airport train to the city center. The trip to the downtown Central Station takes around 15 minutes at an approximate cost of DKK 22.50 (Remember to stamp your ticket in one of the yellow machines downstairs by the train tracks)
Registration
and Payment
Please complete the Registration
Form and return it to the EUFEPS Secretariat. The registration
fee (EUFEPS Membership 10 % reduction) includes all conference
documentation, all coffee breaks, three lunches and poster session
refreshments. The cost for hotel accommodation and travel is
not included in the registration fee.
| Conference
Registration Fees EUR |
EUFEPS |
EUFEPS |
EUFEPS |
EUFEPS |
|
Members
before February 2, 2004 |
Non-Members
before February 2, 2004 |
Members
after February 2, 2004 |
Non-Members
after February 2, 2004 |
|
| Industrial
delegate |
1000 |
1200 |
1200 |
1400 |
| Academic
delegate |
500 |
600 |
600 |
700 |
| Government
delegate |
500 |
600 |
600 |
700 |
| Student
delegate |
250 |
300 |
300 |
350 |
Hotel
Reservation
A number of rooms have been reserved at specially reduced rates.
For Hotel categories and rates (including VAT), see the Hotel
Reservation Form. Complete the Hotel Reservation Form and
send it to the DIS Congress Service Copenhagen, Herlev Ringvej
2C, DK-2730 Herlev, Denmark,
Phone: +45 4492 4492, Fax: +45 4492 5050.
Cancellations
Pre-registered delegates who are unable to attend the Conference
will be refunded, except for an administrative fee of EUR 30,
provided the Conference Secretariat receives a written notice
of non-attendance, before March 12, 2004.
No refunds can be made for cancellations received after this
date. Substitutions may, however, be made at any time. The name
of the substitute/s should be forwarded to the Conference Secretariat.
Hotel reservations will only be valid after the deposit has
been received. Please note that reservations are made on a first-come
first served basis at the time of receipt of deposit payment
(per room) by the DIS Congress Service Copenhagen A/S. If the
price level of your choice is not available at the time of booking,
the closest alternative will be allocated. In case of cancellation
or changes after 17 January 2004, the deposit will only be refunded
– less a hotel-processing fee of DKK 350 – if the
Conference Bureau is able to allocate the room to another guest.
All changes must be made to DIS Conference Service Copenhagen
A/S in writing, and not to the hotel. The deposit serves as
a guarantee to the hotel for the first night and will be deducted
from the participants’ hotel bill upon checkout. Hotel
deposit can only be paid by valid credit card.
Additional
Information
Contact the EUFEPS Secretariat (address below) for copies of
announcements, the Preliminary Programme and Registration Form.
Also, inform your colleagues about this important Conference.
| Conference
Secretariat |
Hotel
Reservation |
Conference Venue |
| EUFEPS
Secretariat Attn: Annika Nyman PO Box 1136 SE-111 81 Stockholm, Sweden Phone: +46 8 7235000 Fax: +46 8 4113217 Email: conferences@eufeps.org |
DIS
Congress Service Copenhagen Herlev Ringvej 2C DK-2730 Herlev Denmark Phone: +45 4492 4492 Fax: +45 4492 5050 Email: dis@discongress.com Website http://www.discongress.com |
Moltke’s
PalaceDronningens Tvaergade 2, Copenhagen KDK-1302 Denmark Phone: +45 3314 8066 Fax: +45 3315 9106 Website http://www.moltkes.dk |
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|
| Strøget, Copenhagen. |
The European Federation for Pharmaceutical Sciences – EUFEPS
Box 1136 SE - 111 81 Stockholm, Sweden
Tel +46 8 7235000 Fax +46 8 4113217 Email secretariat@eufeps.org
